Joint and Muscle Pain in Menopause

As women age, joint and muscle discomfort can become more noticeable. Soreness, stiffness, or aches may seem to appear “overnight,” often worse in the morning or after rest. Hormonal changes, especially declining estrogen, play a key role, contributing to inflammation, reduced muscle tone, and weaker connective tissues. Postmenopausal women commonly report musculoskeletal discomfort, sometimes overlapping with autoimmune or rheumatologic conditions.

Estrogen helps maintain collagen and muscle strength, including the pelvic floor. Its decline can reduce oxygen and nutrient delivery to tissues, weaken muscles, and slow repair, increasing the risk of joint pain, muscle aches, and pelvic floor issues such as prolapse.

• Sore or stiff joints

• Muscle aches or generalized body pain

• Dull, throbbing, or shooting pain

• Cramps or spasms 

• Estrogen - Helps preserve muscle tone, connective tissue elasticity, and joint health. Its decline can accelerate “inflammaging,” worsen autoimmune symptoms, and increase nerve sensitivity.

• Progesterone - Fluctuations may contribute to muscle tension and discomfort.   

• Testosterone - Supports muscle maintenance and bone density.    

 Age-related muscle loss and fat gain contribute to slower metabolism and reduced muscle support for joints. Declining estrogen amplifies these effects, weakening muscles, tissues, and connective fibers, which may increase pain and stiffness. 

Consult a healthcare provider if you experience persistent joint swelling, stiffness, or pain, especially in the hands, knees, or feet, or if symptoms worsen over time.