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      • Progesterone
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  • Home
  • Understanding Menopause
    • Perimenopause
    • Menopause
    • Postmenopause
  • Symptoms
    • Common Symptoms
    • Hot Flash & Night Sweats
    • Cycle Change & Heavy Flow
    • Vaginal Health & Libido
    • Sleep Issues in Menopause
    • Brain Fog & Memory
    • Mood & Emotional Health
    • Fatigue & Low Energy
    • Weight & Metabolism
    • Hair Loss & Skin Aging
    • Joint & Muscle Pain
    • Urinary Health
    • Other Menopausal Symptoms
  • Hormones
    • Hormones and Menopause
    • Estrogen
    • Progesterone
    • Testosterone
    • GnRH, FSH & LH
  • Therapy options
    • Symptom Treatment Options
    • MHT
    • Delivery of MHT
    • Non-Hormonal Therapies
    • Lifestyle Changes
  • In the News
    • Menopause in the News
  • Resources
    • Books Available
    • Helpful Links
  • About
  • Osteoporosis

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Menopausal Hormone Therapy (MHT)

What is MHT?

Menopausal Hormone Therapy (MHT), previously known as Hormone Replacement Therapy (HRT), is the use of estrogen, with or without progestogen, to relieve menopause symptoms caused by declining hormone levels.


MHT can help restore balance, ease daily discomforts, and support long-term health when used safely and appropriately. 

How MHT Works

 During perimenopause and menopause, estrogen levels fall, affecting many parts of the body — from temperature regulation and mood to bone and heart health.


MHT supplements estrogen (and sometimes progesterone) to help restore hormonal stability, reduce symptoms, and protect certain tissues, such as the bones and urogenital tract. 

Types of MHT

Estrogen MHT

 MHT is not a one-size-fits-all treatment. There are several types, depending on the hormones used and how they are delivered. 


 MHT should be individualized. Talk with your healthcare provider to find the right type, dose, and timing of therapy. 

Progesterone MHT

  Sometimes used for women with estrogen-sensitive conditions or to manage abnormal uterine bleeding. 


Testosterone MHT

 Sometimes added to estrogen therapy 


  Used off-label to address low libido in postmenopausal women. Requires careful monitoring. 

Tibolone MHT

 Often used in Europe; may help with mood, libido, and bone health. Not typically used in women with a history of breast cancer. 

Talk with your healthcare provider to find the right type, dose, and timing of therapy. 

Bioidentical Hormone Therapy

Bioidentical hormones are compounds that have the same chemical structure as the hormones naturally produced by the human body, such as estrogen, progesterone, and testosterone. Because of this molecular similarity, bioidentical hormones can interact with hormone receptors in the body in the same way as endogenous hormones. 

Types of Bioidentical Hormones

Bioidentical hormones can be found in two main forms:


  1. Regulated (FDA-approved) bioidentical hormones
    These are standardized formulations that have been tested for safety, efficacy, and purity. Common examples include estradiol and micronized progesterone, available in patches, gels, sprays, and oral tablets.


These products are prescribed by healthcare providers and produced under strict quality controls.
 

  1. Compounded bioidentical hormones
    These are custom-mixed formulations prepared by compounding pharmacies, often marketed as “natural” or “customized” alternatives. They may combine different doses or delivery forms (such as creams, lozenges, or pellets) tailored to individual hormone testing or preferences.


However, compounded bioidentical hormones are not regulated or approved by the FDA, meaning their potency, safety, and consistency can vary.

Menopausal Hormone Therapy

Benefits at a Glance

When started around the time of menopause, MHT can:


  • Reduce hot flashes and night sweats
     
  • Improve sleep, mood, and energy
     
  • Improve vaginal and urinary health

Risks and Considerations

Like all medical treatments, MHT has potential risks.


These depend on factors such as age, time since menopause, overall health, and type of therapy used.


Possible risks include:


  • Blood clots (mainly with oral estrogen)
     
  • Slightly increased breast cancer risk with long-term combined therapy
     
  • Gallbladder disease
     
  • Stroke risk in older women starting therapy later in life

Personalized Treatment

Your ideal MHT plan depends on your symptoms, health history, and personal preferences.


A healthcare provider can help determine:


  • Whether you need estrogen-only or combined therapy
     
  • Which route (oral, patch, gel, vaginal) best fits your needs
     
  • The lowest effective dose for the shortest time necessary

Additional Resource on Hormone Therapy

The Cleveland Clinic

A great place to learn more and complement what you’ve read here. 

Learn more at The Cleveland Clinic

Related Pages

Delivery of MHT

  This website provides general information to help you better understand menopause and related topics, as explored in the Menopause Spotlight books. It is not medical advice and should not replace guidance from a qualified healthcare professional. Always consult your doctor or other healthcare provider with any questions about your health, treatments, or symptoms. 

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